Anti-CD3

Anti-CD3 Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Anti-CD3 is 93% monomeric immune globulin G type 2a (IgG2a).

Used in organ transplant prophylaxis, Anti-CD3 or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

Anti-CD3
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Trade Name	Anti-CD3
Generic	Muromonab
Muromonab Other Names	Anti-CD3, Muromonab-CD3
Type
Formula	C₆₄₆₀H₉₉₄₆N₁₇₂₀O₂₀₄₃S₅₆
Weight	146189.7 Da
Groups	Approved, Investigational
Therapeutic Class
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Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Anti-CD3 is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.

For treatment of organ transplant recipients, prevention of organ rejection

Anti-CD3 is also used to associated treatment for these conditions: Kidney Transplant Rejection, Steroid resistant Heart transplant rejection, Steroid resistant hepatic transplant rejection

How Anti-CD3 works

Anti-CD3 binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.