Pre-Pen

Pre-Pen Uses, Dosage, Side Effects, Food Interaction and all others data.

Pre-Pen is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.

Benylpenicilloyl polylysine is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. If skin testing using benzylpenicilloyl and penicillin G (as the sole source of minor determinants) is negative, approximately 97% of patients with a negative skin test will tolerate penicillin.

Table Of contents

• Pre-Pen
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Pre-Pen
Generic	Benzylpenicilloyl polylysine
Benzylpenicilloyl polylysine Other Names	Benzyl penicilloyl-polylysine, Benzylpenicilloyl G polylysine, Benzylpenicilloyl polylysine, Benzylpenicilloyl-polylysine
Type	Injection
Formula	C28H46N6O8S
Weight	Average: 626.765 Monoisotopic: 626.309783168
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pre-Pen is a penicillin derivative used to determine penicillin allergies.

For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).

Pre-Pen is also used to associated treatment for these conditions: Penicillin Allergy, Beta-lactam antibiotic allergy

How Pre-Pen works

The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Pre-Pen reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.

Toxicity

Symptoms of overdose include urticaria, generalized pruritus, local swelling, generalized flushing, anaphylaxis, bronchospasm, fainting and maculopapular eruption.

Food Interaction

No interactions found.

Innovators Monograph

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