(R)-flurbiprofen
(R)-flurbiprofen Uses, Dosage, Side Effects, Food Interaction and all others data.
(R)-flurbiprofen is an investigational drug that was studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's disease patients. In June 2008 development of the drug for Alzheimer's disease was discontinued. (R)-flurbiprofen has also been used in trials studying the treatment of Prostate Cancer.
| Trade Name | (R)-flurbiprofen |
| Generic | Tarenflurbil |
| Tarenflurbil Other Names | (R)-flurbiprofen, Tarenflurbil |
| Type | |
| Formula | C15H13FO2 |
| Weight | Average: 244.2609 Monoisotopic: 244.089957865 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in alzheimer's disease and prostate cancer.
How (R)-flurbiprofen works
MPC-7869 is not an inhibitor of cyclooxygenase enzymes (COX-1 and COX-2). The compound modulates the signal transduction and transcription activation pathways associated with nuclear factor kappaB (NFkappaB), a principle transcription factor in the expression of many molecules involved in cell growth, cell death and inflammation. In addition, MPC-7869 has recently been shown to modulate gamma-secretase and selectively lower levels of Abeta42 peptide in vitro and in vivo, and to reduce amyloid pathology in the brain. MPC-7869 has an excellent safety profile and is very potent in animal models of cancer and Alzheimer's disease. In transgenic mouse studies, MPC-7869 reduced brain amyloid levels and prevented memory loss.
Innovators Monograph
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