Recombinant Human Mannan-binding Protein
Recombinant Human Mannan-binding Protein Uses, Dosage, Side Effects, Food Interaction and all others data.
Recombinant Human Mannan-binding Protein is a protein therapeutic being developed by Enzon for the prevention and treatment of severe infections in individuals with low levels of Mannose-Binding Lectin (MBL). Over 10 percent of the general population is estimated to be MBL-deficient. Natural MBL is a 400-700kDa oligomer made of 3 identical 32kDa peptide chains.
MBL forms different oligomers but must form at least a tetramer to be active.
| Trade Name | Recombinant Human Mannan-binding Protein |
| Generic | rhMBL |
| rhMBL Other Names | Recombinant human mannan-binding protein, Recombinant human mannose-binding lectin, rhMBP |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in immunodeficiency and infectious and parasitic disease (unspecified).
How Recombinant Human Mannan-binding Protein works
MBL deficiency may explain why some but not all individuals who are immunosuppressed develop infectious complications even when they receive prophylactic anti-infectious treatment. Studies have shown a correlation between low MBL levels and susceptibility to serious infections in patients immunosuppressed from chemotherapy, including patients with multiple myeloma undergoing high-dose chemotherapy and hematopoietic stem cell transplantation. Recombinant Human Mannan-binding Protein acts as natural MBL in the body, reducing susceptibility to serious infections.
Innovators Monograph
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