Refametinib

Refametinib Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Refametinib
Generic Refametinib
Refametinib Other Names Refametinib
Type
Formula C19H20F3IN2O5S
Weight Average: 572.337
Monoisotopic: 572.008970485
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Refametinib
Refametinib

Uses

Investigated for use/treatment in cancer/tumors (unspecified).

How Refametinib works

RDEA119 is a potent, non-ATP competitive, highly selective inhibitor of MEK. RDEA119 is a highly potent and selective inhibitor of mitogen-activated ERK kinase (MEK), a key component of the RAS/RAF/MEK/ERK pathway that is commonly defective in human tumors. The MEK1/2 pathway is important in cell cycle regulation in inflammatory bowel disease, including ulcerative colitis and Crohn's disease. RDEA119 was shown to reduce damage to colonic tissue in two different mouse models of colitis, murine trinitrobenzene sulfonic acid (TNBS) colitis model and murine dextran sulfate sodium (DSS) colitis model. [Ardea Biosciences Inc. Press release]

Innovators Monograph

You find simplified version here Refametinib

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