6-{[6-(1-methyl-1H-pyrazol-4-yl)[1

6-{[6-(1-methyl-1H-pyrazol-4-yl)[1 Uses, Dosage, Side Effects, Food Interaction and all others data.

A MET receptor tyrosine kinase inhibitor.

Table Of contents

• 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	6-{[6-(1-methyl-1H-pyrazol-4-yl)[1
Generic	SGX-523
SGX-523 Other Names	6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
Type
Formula	C18H13N7S
Weight	Average: 359.408 Monoisotopic: 359.095314141
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in solid tumors and cancer/tumors (unspecified).

How 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1 works

SGX523 is selective inhibitor of the receptor tyrosine kinase MET. MET is implicated in development and progression of cancer. SGX523 ihibits MET autophosphorylation and signalling, as well as activates cysteine-aspartic acid protease 3 (caspase 3), an enzyme which is part of the apoptosis signalling cascade.

Innovators Monograph

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