6-{[6-(1-methyl-1H-pyrazol-4-yl)[1

6-{[6-(1-methyl-1H-pyrazol-4-yl)[1 Uses, Dosage, Side Effects, Food Interaction and all others data.

A MET receptor tyrosine kinase inhibitor.

Trade Name 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1
Generic SGX-523
SGX-523 Other Names 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
Type
Formula C18H13N7S
Weight Average: 359.408
Monoisotopic: 359.095314141
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
6-{[6-(1-methyl-1H-pyrazol-4-yl)[1
6-{[6-(1-methyl-1H-pyrazol-4-yl)[1

Uses

Investigated for use/treatment in solid tumors and cancer/tumors (unspecified).

How 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1 works

SGX523 is selective inhibitor of the receptor tyrosine kinase MET. MET is implicated in development and progression of cancer. SGX523 ihibits MET autophosphorylation and signalling, as well as activates cysteine-aspartic acid protease 3 (caspase 3), an enzyme which is part of the apoptosis signalling cascade.

Innovators Monograph

You find simplified version here 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1

*** Taking medicines without doctor's advice can cause long-term problems.
Share