Immunoglobulin G1

Uses

Immunoglobulin G1 is an antineoplastic agent and SLAMF7-directed immunostimulatory antibody used for the treatment of refractory multiple myeloma in combination with other antineoplastic agents.

Indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies.

Immunoglobulin G1 is also used to associated treatment for these conditions: Refractory Multiple Myeloma

How Immunoglobulin G1 works

Immunoglobulin G1 is a humanized IgG1 monoclonal antibody that specifically targets the SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7) protein. SLAMF7 is expressed on myeloma cells independent of cytogenetic abnormalities. SLAMF7 is also expressed on Natural Killer cells, plasma cells, and at lower levels on specific immune cell subsets of differentiated cells within the hematopoietic lineage. Immunoglobulin G1 directly activates Natural Killer cells through both the SLAMF7 pathway and Fc receptors. Immunoglobulin G1 also targets SLAMF7 on myeloma cells and facilitates the interaction with Natural Killer cells to mediate the killing of myeloma cells through antibody-dependent cellular cytotoxicity (ADCC). In preclinical models, the combination of elotuzumab and lenalidomide resulted in enhanced activation of Natural Killer cells that was greater than the effects of either agent alone and increased anti-tumor activity in vitro and in vivo.

Food Interaction

Immunoglobulin G1 Hypertension interaction

[Major] The use of monoclonal antibodies administered via IV infusion may cause serious infusion reactions, including bronchospasm, hypoxia, dyspnea, fluctuations in blood pressure, laryngeal edema and pulmonary edema.

Caution should be taken in patients with a history of cardiopulmonary disease as they may require additional post-infusion medications to manage respiratory complications.

It is recommended to administer required intravenous hydration and premedication with antihistamines, analgesics, and antipyretics before administration.

Monitor closely for signs and symptoms of infusion reactions during and for at least 4 hours following completion of each infusion in a setting where cardiopulmonary resuscitation medication and equipment are available.

Immediately interrupt or permanently discontinue treatment and institute supportive management for severe or prolonged infusion reactions as appropriate.

Immunoglobulin G1 Drug Interaction

Moderate: lactobacillus acidophilus, pomalidomideUnknown: naproxen, alpha-lipoic acid, aspirin, hydroxyzine, amoxicillin / clavulanate, azithromycin, alpha-d-galactosidase, calcium / vitamin d, calcium / vitamin d, multivitamin with minerals, loratadine, ethanol, loperamide, lenalidomide, tramadol, cyanocobalamin, pyridoxine, zoledronic acid

Immunoglobulin G1 Disease Interaction

Major: infections, infusion reactions, tumor lysis syndromeModerate: liver dysfunction

Clearance

The clearance of elotuzumab decreased from a geometric mean (CV%) of 17.5 (21.2%) to 5.8 (31%) mL/day/kg with an increase in dose from 0.5 (i.e., 0.05 times the recommended dosage) to 20 mg/kg (i.e., 2 times the recommended dosage). Based on a population PK model, when elotuzumab is given in combination with lenalidomide and dexamethasone, approximately 97% of the maximum steady-state concentration is predicted to be eliminated with a geometric mean (CV%) of 82.4 (48%) days.

Innovators Monograph

You find simplified version here Immunoglobulin G1