RGM-CSF
RGM-CSF Uses, Dosage, Side Effects, Food Interaction and all others data.
RGM-CSF is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
RGM-CSF is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.
Trade Name | RGM-CSF |
Availability | Prescription only |
Generic | Sargramostim |
Sargramostim Other Names | rGM-CSF, rHu GM-CSF, Sargramostim |
Related Drugs | fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag |
Type | |
Formula | C639H1006N168O196S8 |
Weight | 14434.5 Da |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
RGM-CSF is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.
For the treatment of cancer and bone marrow transplant
RGM-CSF is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy
How RGM-CSF works
RGM-CSF binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Food Interaction
No interactions found.RGM-CSF Drug Interaction
Unknown: amphotericin b lipid complex, isotretinoin, tocilizumab, corticotropin, alteplase, loxapine, fluticasone / salmeterol, theophylline, ketotifen ophthalmic, aluminum hydroxide, testosterone, umeclidinium / vilanterol, dolasetron, hydralazine, mesalamine, ethinyl estradiol / norethindrone, darbepoetin alfa, leflunomide, donepezil, benazepril
RGM-CSF Disease Interaction
Major: arrhythmia, fluid retention, hepatic dysfunction, leukocytosis, myeloid tumors, prematurity, renal dysfunction, respiratory symptoms
Clearance
- 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
- 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
- 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
- 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]
Innovators Monograph
You find simplified version here RGM-CSF