Skin and Seborrhea

Skin and Seborrhea Uses, Dosage, Side Effects, Food Interaction and all others data.

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.

Trade Name Skin and Seborrhea
Generic Arsenic trioxide + oyster shell calcium carbonate + crude + graphite + delphinium staphisagria seed + sulfur liquid
Type For animal use only
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Skin and Seborrhea
Skin and Seborrhea

Uses

Arsenic trioxide is a chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy.

For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression

Skin and Seborrhea is also used to associated treatment for these conditions: Refractory Acute Promyelocytic Leukemia

How Skin and Seborrhea works

The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. It is suspected that arsenic trioxide induces cancer cells to undergo apoptosis.

Toxicity

Symptoms of overdose include convulsions, muscle weakness and confusion.

Elimination Route

Trivalent arsenic is mostly methylated in humans and excreted in urine.

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