Sulphofurazole
Sulphofurazole Uses, Dosage, Side Effects, Food Interaction and all others data.
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
Sulphofurazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Trade Name | Sulphofurazole |
Availability | Discontinued |
Generic | Sulfisoxazole |
Sulfisoxazole Other Names | Sulfadimethylisoxazole, Sulfafurazol, Sulfafurazole, Sulfafurazolum, Sulfaisoxazole, Sulfasoxazole, Sulfisonazole, Sulfisoxasole, Sulfisoxazol, Sulfisoxazole, Sulfofurazole, Sulphadimethylisoxazole, Sulphafurazol, Sulphafurazole, Sulphaisoxazole, Sulphisoxazol, Sulphofurazole |
Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, dexamethasone, levofloxacin |
Type | |
Formula | C11H13N3O3S |
Weight | Average: 267.304 Monoisotopic: 267.067761987 |
Groups | Approved, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sulphofurazole is a sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.
For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Sulphofurazole is also used to associated treatment for these conditions: Acute Otitis Media
How Sulphofurazole works
Sulphofurazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Toxicity
LD50=6800 mg/kg (Orally in mice)
Food Interaction
No interactions found.Sulphofurazole Drug Interaction
Moderate: lactobacillus acidophilusUnknown: fluticasone / salmeterol, amoxicillin, multivitamin, sulfamethoxazole / trimethoprim, meperidine, albuterol / ipratropium, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, ofloxacin, penicillin v potassium, montelukast, tiotropium, budesonide / formoterol, benzonatate, ampicillin / sulbactam, albuterol, albuterol, cholecalciferol
Sulphofurazole Disease Interaction
Major: colitis, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: crystalluria, hemodialysis, urinary obstruction
Elimination Route
The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is intact drug, with the remaining as the N4-acetylated metabolite. It is excreted in human milk.
Innovators Monograph
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