Tebamide

Tebamide Uses, Dosage, Side Effects, Food Interaction and all others data.

Tebamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Trade Name Tebamide
Availability Prescription only
Generic Trimethobenzamide
Trimethobenzamide Other Names Trimethobenzamide, Trimethobenzamidum, Trimetobenzamida
Related Drugs hydroxyzine, lorazepam, ondansetron, Zofran, meclizine, promethazine
Type
Formula C21H28N2O5
Weight Average: 388.4574
Monoisotopic: 388.199822016
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tebamide
Tebamide

Uses

Tebamide is an antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Tebamide is also used to associated treatment for these conditions: Nausea, Nausea and vomiting

How Tebamide works

The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.

Toxicity

Oral LD50 in mice is 1600 mg/kg.

Food Interaction

  • Avoid alcohol. Ingestion of alcohol may increase the CNS depressant effects of trimethobenzamide causing drowsiness.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Half Life

The mean elimination half-life of trimethobenzamide is 7 to 9 hours.

Elimination Route

Between 30 – 50% of a single dose in humans is excreted unchanged in the urine within 48–72 hours.

Innovators Monograph

You find simplified version here Tebamide

*** Taking medicines without doctor's advice can cause long-term problems.
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