Tolazolina Uses, Dosage, Side Effects and more
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazolina can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Tolazolina is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
| Trade Name | Tolazolina |
| Availability | Discontinued |
| Generic | Tolazoline |
| Tolazoline Other Names | 2-Benzylimidazoline, Benzazoline, Tolazolin, Tolazolina, Tolazoline, Tolazolinum |
| Type | |
| Formula | C10H12N2 |
| Weight | Average: 160.2157 Monoisotopic: 160.100048394 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Tolazolina is a vasodilator used to treat pulmonary artery anomalies.
For the treatment of pulmonary artery anomalies
How Tolazolina works
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazolina usually reduces pulmonary arterial pressure and vascular resistance.
Drug Interaction
Unknown: aspirin, barium sulfate, dexamethasone, dextran, low molecular weight, dextran, high molecular weight, epoetin alfa, ginkgo, glipizide, glycerin, guanidine, sodium iodide, arginine, morphine, acetaminophen, procaine penicillin, saccharomyces boulardii lyo, methyl salicylate topical, valproic acid, multivitamin, multivitamin
Disease Interaction
Major: vascular dysfunctionModerate: acid-base balance, histamine release, renal dysfunction
