Tonapofylline

Tonapofylline Uses, Dosage, Side Effects, Food Interaction and all others data.

Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.

Trade Name Tonapofylline
Generic Tonapofylline
Tonapofylline Other Names Tonapofylline
Type
Formula C22H32N4O4
Weight Average: 416.522
Monoisotopic: 416.242355526
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tonapofylline
Tonapofylline

How Tonapofylline works

Stimulation of A1 adenosine receptors in the kidney reduces glomerular filtration rate (GFR) via tubuloglomerular feedback and increases sodium reabsorption. Blocking A1 adenosine receptors would therefore maintain GFR and cause natriuresis. Tonapofylline is a xanthine derivative that binds with high affinity to A1 adenosine receptors from several species including human and acts as a competitive antagonist at these receptors.

Innovators Monograph

You find simplified version here Tonapofylline

*** Taking medicines without doctor's advice can cause long-term problems.
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