Tonapofylline Uses, Dosage, Side Effects and more
Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
| Attribute | Details |
|---|---|
| Trade Name | Tonapofylline |
| Generic | Tonapofylline |
| Tonapofylline Other Names | Tonapofylline |
| Type | |
| Formula | C22H32N4O4 |
| Weight | Average: 416.522 Monoisotopic: 416.242355526 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
How Tonapofylline works
Stimulation of A1 adenosine receptors in the kidney reduces glomerular filtration rate (GFR) via tubuloglomerular feedback and increases sodium reabsorption. Blocking A1 adenosine receptors would therefore maintain GFR and cause natriuresis. Tonapofylline is a xanthine derivative that binds with high affinity to A1 adenosine receptors from several species including human and acts as a competitive antagonist at these receptors.
