Tonzonium
Tonzonium Uses, Dosage, Side Effects, Food Interaction and all others data.
Tonzonium is a monocationic surface-active agent with surfactant and detergent properties. It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of the administered medication. A common pharmaceutical formulation of thonzonium bromide is cortisporin-TC ear drops. It is also reported that thonzonium also confers an antifungal property and antiresorptive effect on bone.
Tonzonium bromide causes dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of the active ingredients contained in the administered medication. It is an inhibitor of vacuolar ATPase that uncouples and blocks the function of the pump without inhibiting ATP hydrolysis.
| Trade Name | Tonzonium |
| Generic | Thonzonium |
| Thonzonium Other Names | Tonzonium |
| Type | |
| Formula | C32H55N4O |
| Weight | Average: 511.818 Monoisotopic: 511.437038827 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tonzonium is a cationic surfactant used to disperse exudate and cellular debris, as well as enhance the penetration of antimicrobials.
Used as a monocationic surfactant and detergent to help penetration of active ingredients through cellular debris for its antibacterial action.
Tonzonium is also used to associated treatment for these conditions: Acute otittis externa caused by Pseudomonas aeruginosa
How Tonzonium works
Tonzonium bromide is a suface-active agent added in nasal and ear drops that potentiates and lenghten the time of skin contact with the active compounds and penetration through the cellular debris. Tonzonium bromide uncouples vacuolar ATPase in pathogenic fungi such as Candida albicans and inhibit cell growth in vitro. It interacts with the tether of subunit a (Vph1p) of the membrane-bound V0 subunit that forms the proton transport path. Disruption of the essential pump function prevents redistribution of cytosolic protons into the vacuolar lumen, resulting in acidification of the cytosol and cell death [A19501]. A study reports that thonzonium bromide mediates an antiresorptive action on osteoclasts by inhibiting RANKL-induced osteoclast formation. It is shown to block the RANKL-induced activation of NF-jB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. It also disrupted F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption .
Toxicity
Unwanted effects include irritation and allergic reactions.
Food Interaction
No interactions found.Innovators Monograph
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