Triclocarban
Triclocarban Uses, Dosage, Side Effects, Food Interaction and all others data.
Triclocarban, with the chemical formula C13H9Cl3N2O is an antibacterial agent that is particularly effective against Gram-positive bacteria such as Staphylococcus aureus. It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products. In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer antiseptic wash products containing triclocarban due to negative health effects such as bacterial resistance or hormonal effects , .
The antimicrobial mechanism underlying the bacteriostatic and bactericidal effects of triclocarban is believed to be an unspecific adsorption to cell membranes and interruption of their function. As a result, the growth of gram-positive as well as gram-negative bacteria is inhibited .
| Trade Name | Triclocarban |
| Generic | Triclocarban |
| Triclocarban Other Names | Triclocarban |
| Type | |
| Formula | C13H9Cl3N2O |
| Weight | Average: 315.58 Monoisotopic: 313.978046 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Triclocarban is an antibacterial agent used in liquid soaps and body washes.
Triclocarban (TCC), or 3,4,4'-trichlorocarbanilide, is an antibacterial agent used in bar and liquid soaps and body washes .
How Triclocarban works
Triclocarban is a triclosan analog with an antibacterial activity. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, which is ubiquitously distributed in bacteria, fungi and various plants. ACP reductase catalyzes the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition .
Toxicity
Ld50 of 2100 mg/kg in mice .
There has been concern voiced over the endocrine effect of triclocarban ande, in particular, on estrogen , ,,.
One study determined that triclocarban by itself stimulates AroB (brain aromatase) gene expression only slightly, but TCC strongly enhances the overexpression of AroB that is induced by exogenous estrogen. TCC has the potential to elevate levels of aromatase enzymes and, thereby, levels of endogenous estrogens in the developing brain . The effects of triclocarban on the endocrine system are presently not fully elucidated.
Food Interaction
No interactions found.Elimination Route
A human exposure study in a small group of subjects demonstrated that a portion of the TCC present in bar soaps is absorbed through the skin and is excreted in urine as N-glucuronides .
Because they are produced and used in large quantities in various products, they are absorbed into the human body of the general population .
The absorption of triclocarban during a human pharmacokinetic study was estimated at 0.6% of the 70 + or - 15 mg of triclocarban in the soap used. The triclocarban-N-glucuronide urine concentration varied considerably among the study subjects, and continuous daily use of the soap led to steady-state levels of excretion .
Half Life
10 hours
Clearance
After a pharmacokinetic study in man, radioactivity was rapidly cleared from blood after intravenous administrations of (14)C-triclocarban in propylene glycol with a blood clearance half-life measured to be 8.6 hours .
Elimination Route
The metabolism of (14)C-TCC (3,4,4'-trichlorocarbanilide) has been investigated in humans following oral exposure to 2.2 mumol/kg. Fecal elimination (70% of dose) was complete at the 120 hour point after administration and the urinary excretion (27% of dose) was complete after 80 hours post-administration .
Urinary glucuronides appear to be valuable biomarkers of triclocarban exposure .
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