Macrogol 300

Macrogol 300 Uses, Dosage, Side Effects, Food Interaction and all others data.

Macrogol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They serve as solubilizers, excipients, lubricants, and chemical reagents. Low molecular weight glycols are observed to exhibit antibacterial properties as well. PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.

PEGs act as nonionic surfactant to decrease surface tension and condition the stratum corneum, thus enhance the diffusion of other molecules or drugs through the skin .

Macrogol 300
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Macrogol 300
Generic	Polyethylene glycol 300
Polyethylene glycol 300 Other Names	Macrogol 300, PEG 300, PEG-6
Type
Protein binding	No pharmacokinetic data available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.

How Macrogol 300 works

Due to their physical properties, PEG acts as a surfactant by coating the eye. It provides lubrication and surface protection in dry eyes.

Toxicity

Oral LD50 in rat and mouse are 27500 mg/kg and 31000 mg/kg, respectively . Dermal LD50 is reported to be 20000 mg/kg in rabbit . PEGs and their derivatives are not known to cause ocular and dermal irritation, and are associated with low acute and chronic toxicities .

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

PEGs can be absorbed by the gastrointestinal tract following oral administration with the fraction absorbed being dependent on the molecular weight of the compound . It is likely to display minimal absorption through the intact skin, but may penetrate through injured skin with compromised barrier function .