Verazine

Verazine Uses, Dosage, Side Effects, Food Interaction and all others data.

Verazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Verazine was first introduced as an anthelmintic in 1953. Verazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Verazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Verazine hydrate and piperazine citrate are the main anthelminthic piperazines.

Trade Name Verazine
Availability Discontinued
Generic Piperazine
Piperazine Other Names Diethylenediamine, Piperazidine, Piperazin, Piperazina, Piperazine
Related Drugs albendazole, mebendazole, nitazoxanide, pyrantel, Albenza, Alinia, Emverm, Ascarel
Weight 750mg/5ml
Type Syrup
Formula C4H10N2
Weight Average: 86.1356
Monoisotopic: 86.08439833
Protein binding

60-70%

Groups Approved, Vet approved
Therapeutic Class
Manufacturer Krka-pak Pharmaceutical & Chemical Works
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Verazine
Verazine

Uses

Verazine is a medication used to treat roundworm and pinworm.

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

Verazine is also used to associated treatment for these conditions: Ascaris lumbricoides infection, Enterobius vermicularis infection

How Verazine works

Verazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Toxicity

LD50 = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Elimination Route

Rapidly absorbed from the gastrointestinal tract

Innovators Monograph

You find simplified version here Verazine

*** Taking medicines without doctor's advice can cause long-term problems.
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