Zefazone

Zefazone Uses, Dosage, Side Effects, Food Interaction and all others data.

A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.

Zefazone is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Zefazone is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.

Trade Name Zefazone
Availability Discontinued
Generic Cefmetazole
Cefmetazole Other Names Cefmetazole, Cefmetazolo, Cefmetazolum
Related Drugs ciprofloxacin, metronidazole, clindamycin, ceftriaxone, vancomycin, cefotaxime, bupivacaine, piperacillin, ropivacaine, Marcaine
Type
Formula C15H17N7O5S3
Weight Average: 471.534
Monoisotopic: 471.045328759
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Zefazone
Zefazone

Uses

Zefazone is a cephalosporin antibiotic used to treat a variety of bacterial infections.

For the treatment of infections caused by susceptible organisms.

Zefazone is also used to associated treatment for these conditions: Susceptible Bacterial Infections

How Zefazone works

The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

Toxicity

Oral LD50 in rats is 3,204 mg/kg. With other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.

Zefazone Alcohol interaction

[Moderate] GENERALLY AVOID:

Some cephalosporins may occasionally induce a disulfiram-like reaction when coadministered with alcohol.

The interaction has been reported for cefamandole, cefoperazone, cefotetan, and moxalactam.

These agents contain an N-methylthiotetrazole (NMTT) side chain that may inhibit aldehyde dehydrogenase (ALDH) similar to disulfiram.

Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'.

Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion.

Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

Cefonicid contains a structurally similar side chain but did not produce elevations in blood acetaldehyde or a disulfiram reaction to ethanol in 15 healthy volunteers given single and multiple one gram doses of the drug.

Patients receiving cephalosporins with the NMTT side chain should avoid the concomitant use of alcohol and alcohol-containing products.

Zefazone Disease Interaction

Moderate: liver disease

Elimination Route

Bioavailability is approximately 100% following intramuscular injection.

Half Life

1.50 ±0.14 hours

Innovators Monograph

You find simplified version here Zefazone

*** Taking medicines without doctor's advice can cause long-term problems.
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