Zimeldina

Zimeldina Uses, Dosage, Side Effects, Food Interaction and all others data.

Zimeldina has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like symptoms, arthralgias, and sometimes eosinophilia. Additionally, zimelidine was charged to cause an increase in suicidal ideation and/or attempts among depressive patients.

Zimeldina was the first marketed selective serotonin reuptake inhibitor (SSRI) antidepressant. It is a pyridylallylamine, structurally different from other antidepressants.

Trade Name Zimeldina
Generic Zimelidine
Zimelidine Other Names Zimeldina, Zimeldine, Zimeldinum
Type
Formula C16H17BrN2
Weight Average: 317.23
Monoisotopic: 316.057512
Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Zimeldina
Zimeldina

Uses

For the treatment of depression.

How Zimeldina works

The antidepressant actions of zimelidine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Zimeldina blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Half Life

8.4 +/- 2.0 hours for the parent compound and 19.4 +/- 3.6 hours for norzimelidine.

Innovators Monograph

You find simplified version here Zimeldina

*** Taking medicines without doctor's advice can cause long-term problems.
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