Carotuximab

Carotuximab Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Carotuximab
Generic Carotuximab
Carotuximab Other Names Carotuximab
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Carotuximab
Carotuximab

Uses

Investigated for use/treatment in solid tumors.

How Carotuximab works

TRC105 is a first-in-class human chimeric monoclonal antibody that inhibits tumor growth by binding to CD105 (endoglin), a receptor over-expressed on proliferating endothelium that is required for angiogenesis (growth of new blood vessels). TRC105 has shown activity, as monotherapy or when combined with chemotherapy, in pre-clinical studies of breast and colorectal cancer. Pre-clinical data also indicate CD105 expression is increased following treatment of human cancer with anti-VEGF therapy. The target of TRC105 shares many features with the VEGF receptor. Most importantly, both the VEGF and CD105 receptors are essential for angiogenesis, in that deletion of either receptor prevents blood vessel formation in utero. [Traecon Pharmaceuticals Press Release]

Innovators Monograph

You find simplified version here Carotuximab

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