Antithrombin III
Antithrombin III Uses, Dosage, Side Effects, Food Interaction and all others data.
Antithrombin III is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.
Hereditary antithrombin deficiency causes an increased risk of venous thromboembolism (VTE). In high risk situations, such as surgery or trauma or for pregnant women during the peri-partum period, the risk of development of VTEs is 10-50 times greater than the general population. In hereditary antithrombin deficient patients antithrombin alfa normalizes plasma antthrombin activity levels during peri-operative and peri-partum periods.
| Trade Name | Antithrombin III |
| Generic | Antithrombin Alfa |
| Antithrombin Alfa Other Names | Antithrombin (recombinant), Antithrombin Alfa, Antithrombin III, recombinant, Antithrombin III,recombinant |
| Type | |
| Protein binding | Binds and inhibits thrombin and factor Xa. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Antithrombin III is a recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency.
Antithrombin alfa is a recombinant antithrombin it is indicated for the prevention of peri-operative and peri-partum thromboembolic events in patients with hereditary deficiency of antithrombin.
Antithrombin III is also used to associated treatment for these conditions: Postoperative Thromboembolism, Postpartum thrombosis
How Antithrombin III works
Antithrombin is the main inhibitor of thrombin and Factor Xa , the serine proteases involved in blood coagulation. Antithrombin neutralizes the activity of thrombin and Factor Xa by forming a complex which is rapidly removed from the circulation.
Toxicity
Highest dose tested was 360mg/kg/day in rats resulted in transient limb swelling.
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Volume of Distribution
Dose of: 50IU/kg: 126.2 ml/kg 100IU/kg: 156.1 ml/kg Vd in hereditary deficient pregnant women in high risk situations had increased Vd of 14.3L.
Elimination Route
Given IV so not absorbed.
Half Life
Dose of: 50IU/kg: 11.6 h 100IU/kg: 17.7 h
Clearance
Dose of: 50IU/kg: 9.6 ml/hr/kg 100IU/kg: 7.2 ml/hr/kg Cl in hereditary deficient pregnant women in high risk situations had increased Cl of 1.38L/h.
Elimination Route
Irreversible complexes formed between antithrombin III and its target protease are rapidly removed by the liver.
Innovators Monograph
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