Clevidipine Butyrate
Clevidipine Butyrate Uses, Dosage, Side Effects, Food Interaction and all others data.
Clevidipine Butyrate is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Clevidipine Butyrate belongs to a well-known class of drugs called dihydropyridine calcium channel antagonists. Clevidpine is the first third generation intravenous dihydropyridine calcium channel blocker. In vitro studies demonstrated that clevidipine acts by selectively relaxing the smooth muscle cells that line small arteries, resulting in arterial dilation, widening of the artery opening, and without reducing central venous pressure or reducing cardiac output.
Trade Name | Clevidipine Butyrate |
Availability | Prescription only |
Generic | Clevidipine |
Clevidipine Other Names | Clevidipine, Clevidipine butyrate, Clevidipino |
Related Drugs | amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, hydralazine, nifedipine, captopril, enalapril |
Type | |
Formula | C21H23Cl2NO6 |
Weight | Average: 456.316 Monoisotopic: 455.090242887 |
Protein binding | >99.5% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clevidipine Butyrate is a dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable.
For the reduction of blood pressure when when oral antihypertensive therapy is not feasible or not desirable.
Clevidipine Butyrate is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)
How Clevidipine Butyrate works
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, clevidipine inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
Food Interaction
No interactions found.Clevidipine Butyrate Alcohol interaction
[Moderate]
Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.
Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
Caution and close monitoring for development of hypotension is advised during coadministration of these agents.
Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.
Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
Clevidipine Butyrate Cholesterol interaction
[Major] Clevidipine Butyrate is contraindicated in patients with defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if it is accompanied by hyperlipidemia.
Clevidipine Butyrate Drug Interaction
Moderate: nebivolol, metoprolol, promethazine, budesonide / formoterolUnknown: fluticasone / salmeterol, irbesartan, ferrous fumarate, ferrous sulfate, acetaminophen, clopidogrel, denosumab, evolocumab, calcitriol, benzonatate, tramadol, albuterol, ascorbic acid, cholecalciferol
Clevidipine Butyrate Disease Interaction
Major: aortic stenosis, lipid dysfunctionModerate: heart failure, hypotension
Half Life
1 minute
Elimination Route
urine 63-74%, feces 7-22%
Innovators Monograph
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