Gabapentine Enacarbil

Gabapentine Enacarbil Uses, Dosage, Side Effects, Food Interaction and all others data.

Gabapentine Enacarbil is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).

Since gabapentin enacarbil is a prodrug of gabapentin, it's physiological effects are the same as gabapentin. Concerning PHN, gabapentin prevents allodynia and hyperalgesia.

Table Of contents

• Gabapentine Enacarbil
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Gabapentine Enacarbil
Generic	Gabapentin enacarbil
Gabapentin enacarbil Other Names	Gabapentin enacarbil, Gabapentina enacarbilo, Gabapentine enacarbil, Gabapentinum enacarbilum
Type
Formula	C16H27NO6
Weight	Average: 329.393 Monoisotopic: 329.183837593
Protein binding	Gabapentin plasma protein binding is less than 3%.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gabapentine Enacarbil is a gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).

For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).

Gabapentine Enacarbil is also used to associated treatment for these conditions: Post-Herpetic Neuralgia (PHN), Restless Legs Syndrome (RLS)

How Gabapentine Enacarbil works

Although the exact mechanism of action of gabapentin in RLS and PHN is unknown, it is presumed to involve the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors.

Toxicity

Most common adverse reactions are headache, dizziness, and somnolence.

Food Interaction

• Take with or without food.

Volume of Distribution

The volume of distribution is 76L.

Elimination Route

Gabapentine Enacarbil is absorbed in the intestines by active transport through the proton-linked monocarboxylate transporter, MCT-1.

Half Life

The elimination half-life of gabapentin is 5.1 to 6.0 hours.

Clearance

Renal clearance of gabapentin is 5 to 7 L/hr.

Elimination Route

Gabapentine Enacarbil is eliminated primarily in the urine (94%) and to a lesser extent in the feces (5%).

Innovators Monograph

You find simplified version here Gabapentine Enacarbil