Dimethyloxoxanthene Acetic Acid
Dimethyloxoxanthene Acetic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Dimethyloxoxanthene Acetic Acid |
| Generic | Vadimezan |
| Vadimezan Other Names | 5,6-MeXAA, Dimethyloxoxanthene acetic acid, DMXAA, Vadimezan, Vadimézan, Vadimezanum |
| Type | |
| Formula | C17H14O4 |
| Weight | Average: 282.2907 Monoisotopic: 282.089208936 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in solid tumors, lung cancer, ovarian cancer, and prostate cancer.
How Dimethyloxoxanthene Acetic Acid works
ASA404 (DMXAA) is a small-molecule vascular disrupting agent which targets the blood vessels that nourish tumours. The proposed mechanism of action for ASA404 is directly increasing permeability of the tumor's endothelial cells. Vasoactive mediators such as tumor necrosis factor (TNF) may also be implicated. Increased permeability of tumor cell vasculature may allow increased permeation of anticancer treatments such as cytotoxic drugs, antibodies, drug conjugates and gene therapy.
Innovators Monograph
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