Dimocillin

Dimocillin Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Dimocillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

Dimocillin
Uses
Dosage
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Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Trade Name	Dimocillin
Generic	Meticillin
Meticillin Other Names	Methicillin, Methicillinum, Methycillin, Meticilina, Meticillin, Meticillina, Meticilline, Meticillinum
Type
Formula	C₁₇H₂₀N₂O₆S
Weight	Average: 380.415 Monoisotopic: 380.104207072
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.

How Dimocillin works

Similar to other beta-lactam antimicrobials, meticillin blocks synthesis of the bacterial cell wall. Dimocillin stops cross-linkage between the peptidoglycan polymer chains, which make up a large portion of gram-positive bacterial cell walls. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.