Recombinant Human Activated Protein C (rH-APC) Uses, Dosage, Side Effects and more

Recombinant Human Activated Protein C (rH-APC) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Recombinant Human Activated Protein C (rH-APC) was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.

Recombinant Human Activated Protein C (rH-APC) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.Recombinant Human Activated Protein C (rH-APC) inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Attribute	Details
Trade Name	Recombinant Human Activated Protein C (rH-APC)
Generic	Drotrecogin alfa
Drotrecogin alfa Other Names	Activated protein C, Blood coagulation factor XIV (human), Drotrecogin alfa (activated), Drotrecogin alfa (activated), lyophilized, Drotrecogin alfa activated, Drotrecogin alfa, activated, Drotrecogin-alfa, Recombinant human activated protein C (rH-APC)
Type
Formula	C₁₇₈₆H₂₇₇₉N₅₀₉O₅₁₉S₂₉
Weight	55000.0 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	January 7, 2025 at 1:49 am

Uses

Recombinant Human Activated Protein C (rH-APC) is a form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

For reduction of mortality in patients with severe sepsis.

How Recombinant Human Activated Protein C (rH-APC) works

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.