Niclocide

Niclocide Uses, Dosage, Side Effects, Food Interaction and all others data.

Niclocide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.

Niclocide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.

Niclocide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.

Trade Name Niclocide
Availability Discontinued
Generic Niclosamide
Niclosamide Other Names Niclosamide
Related Drugs praziquantel, paromomycin, Biltricide, Humatin
Type
Formula C13H8Cl2N2O4
Weight Average: 327.12
Monoisotopic: 325.986112168
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Niclocide
Niclocide

Uses

Niclocide is an anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.

For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclocide is also used as a molluscicide in the control of schistosomiasis.

Niclocide is also used to associated treatment for these conditions: Helminthic infection, Tapeworm infestation

How Niclocide works

Niclocide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclocide may work as a molluscicide by binding to and damaging DNA.

Toxicity

Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort.

Elimination Route

Niclocide appears to be minimally absorbed from the gastrointestinal tract—neither the drug nor its metabolites have been recovered from the blood or urine.

Innovators Monograph

You find simplified version here Niclocide

*** Taking medicines without doctor's advice can cause long-term problems.
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