Lithostat
Lithostat Uses, Dosage, Side Effects, Food Interaction and all others data.
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.
| Trade Name | Lithostat |
| Generic | Acetohydroxamic acid |
| Acetohydroxamic acid Other Names | Acethydroxamsaeure, Acetic acid, oxime, Acetohydroxamate, Acetohydroxamic acid, Acetohydroximic acid, Acetyl hydroxyamino, Acetylhydroxamic acid, Acide acetohydroxamique, Acido acetohidroxamico, Acidum acetohydroxamicum, Cetohyroxamic acid, Methylhydroxamic acid, N-Acetyl hydroxyacetamide, N-Acetylhydroxylamine, N-Hydroxyacetamide |
| Weight | 250mg, |
| Type | Oral tablet |
| Formula | C2H5NO2 |
| Weight | Average: 75.0666 Monoisotopic: 75.032028409 |
| Protein binding | No known binding |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lithostat is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.
Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Lithostat is also used to associated treatment for these conditions: Chronic urea-splitting urinary infection
How Lithostat works
Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.
Toxicity
Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
Food Interaction
- Avoid alcohol. Concomitant use of acetohydroxamic acid with alcohol may cause a rash.
- Avoid iron supplements. Lithostat chelates iron, therefore oral supplementation of iron will reduce levels of both iron and acetohydroxamic acid.
- Take on an empty stomach.
Elimination Route
Well absorbed from the GI tract following oral administration.
Half Life
5-10 hours in patients with normal renal function
Innovators Monograph
You find simplified version here Lithostat
