Monobasic

Monobasic Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.

Sodium phosphate inceases fecal water content to increase mobility through the large intestine .

Trade Name Monobasic
Generic Sodium phosphate, monobasic
Sodium phosphate, monobasic Other Names Monosodium dihydrogen monophosphate, Monosodium dihydrogen orthophosphate, Monosodium monophosphate, Sodium acid phosphate, Sodium dihydrogen phosphate, Sodium orthophosphate, Sodium orthophosphate monobasic, Sodium phosphate monobasic, Sodium phosphate, monobasic, Sodium primary phosphate
Type
Formula H2NaO4P
Weight Average: 119.977
Monoisotopic: 119.958839739
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Monobasic
Monobasic

Uses

Monobasic is a source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.

Used to treat constipation or to clean the bowel before a colonoscopy .

Monobasic is also used to associated treatment for these conditions: Acid-Base Imbalance, Acidosis, Burns, Constipation, Dehydration, Diarrhoea, Drug Poisoning, Electrolyte imbalance, Hypophosphatemia, Mild, moderate Metabolic Acidosis, Bowel preparation therapy, Continuous Renal Replacement Therapy, Electrolyte replacement, Fluid replacement therapy, Parenteral Nutrition, Parenteral rehydration therapy, Total parenteral nutrition therapy, Fluid and electrolyte maintenance, Irrigation of the ocular surface therapy, Red blood cell rejuvination

How Monobasic works

Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen .

Toxicity

Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats . Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma . Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients .

Food Interaction

No interactions found.

Elimination Route

Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h .

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*** Taking medicines without doctor's advice can cause long-term problems.
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