Monobasic
Monobasic Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.
Sodium phosphate inceases fecal water content to increase mobility through the large intestine .
| Trade Name | Monobasic |
| Generic | Sodium phosphate, monobasic |
| Sodium phosphate, monobasic Other Names | Monosodium dihydrogen monophosphate, Monosodium dihydrogen orthophosphate, Monosodium monophosphate, Sodium acid phosphate, Sodium dihydrogen phosphate, Sodium orthophosphate, Sodium orthophosphate monobasic, Sodium phosphate monobasic, Sodium phosphate, monobasic, Sodium primary phosphate |
| Type | |
| Formula | H2NaO4P |
| Weight | Average: 119.977 Monoisotopic: 119.958839739 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Monobasic is a source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.
Used to treat constipation or to clean the bowel before a colonoscopy .
Monobasic is also used to associated treatment for these conditions: Acid-Base Imbalance, Acidosis, Burns, Constipation, Dehydration, Diarrhoea, Drug Poisoning, Electrolyte imbalance, Hypophosphatemia, Mild, moderate Metabolic Acidosis, Bowel preparation therapy, Continuous Renal Replacement Therapy, Electrolyte replacement, Fluid replacement therapy, Parenteral Nutrition, Parenteral rehydration therapy, Total parenteral nutrition therapy, Fluid and electrolyte maintenance, Irrigation of the ocular surface therapy, Red blood cell rejuvination
How Monobasic works
Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen .
Toxicity
Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats . Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma . Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients .
Food Interaction
No interactions found.Elimination Route
Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h .
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