N-alkyl ethylbenzyl dimethyl ammonium (C12-C14)
N-alkyl ethylbenzyl dimethyl ammonium (C12-C14) Uses, Dosage, Side Effects, Food Interaction and all others data.
N-alkyl ethylbenzyl dimethyl ammonium (c12-c14) is a quaternary ammonium compound with surfactant properties. It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties.
Employed in a great variety of cleaning agents and sanitizing agents, it possesses relatively broad gram-positive and gram-negative antibacterial activities and relatively little chance for systemic absorption and exposure, although the formal mechanism of action of quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is difficult to elucidate.
N-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is a quaternary ammonium compound that demonstrates antimicrobial activity . In particular, a high degree of microbiocidal activity in hard water is obtained with a blend of two quaternary ammonium chlorides or bromides where the quaternary ammonium cation of each quaternary component is alkyl dimethyl ethylbenzyl and wherein the the alkyl group in once case is C12 and in the other case is C14, with these compounds being present only within the range of 85/15 to 55/45 of the C12 compound relative to the C14 compound .
| Trade Name | N-alkyl ethylbenzyl dimethyl ammonium (C12-C14) |
| Generic | N-alkyl ethylbenzyl dimethyl ammonium (C12-C14) |
| Type | |
| Protein binding | Readily accessible data regarding the protein binding of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is not available. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
N-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is added to products to function as a cleaning agent, or as antimicrobial agents in disinfecting cleaning products .
How N-alkyl ethylbenzyl dimethyl ammonium (C12-C14) works
Quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride irreversibly bind to the phospholipids and proteins of microbial cell membranes, thereby impairing membrane permeability . Consequently, the antibacterial actions of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride generally stem from the capacity of bacterial cells to absorb the compound, causing the disruption or dissociation of cellular membrane lipid bilayers of bacteria, resulting in compromised cellular permeability control and the leakage of important cellular contents. In particular, the antimicrobial activity of quaternary ammonium with an alkyl chain is related to lipolhilia and peaks between C12 and C16 for both gram-positive and gram-negative bacterial strains . Specifically, in gram-positive bacteria, the agent becomes bound to the wall proteins and is, therefore, able to enter and destroy the membrane . Additionally, in some microbes, n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride can cause a leak in metabolites with low molecular weights, resulting in metabolic injury and modification of permeability for the microbe .
It is for these aforementioned mechanisms of action that n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is capable of eliciting antimicrobial activity when used as a disinfectant . However, when used as an agent for routine cleaning where surface contamination with pathogenic bacteria and viruses does not necessarily present a hazard, the use of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride and its antimicrobial actions may not be entirely necessary or recommended, considering quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride can persist on cleaned surfaces and contribute to prolonged topical exposure to individuals .
Toxicity
An oral dose of 100-400 mg/kg or a parenteral dose of 5-15 mg/kg is believed to be fatal in humans . Other studies propose that the fatal dose of quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is estimated to be between 1-3 grams .
Some adverse effects associated with exposure to a quaternary ammonium compound like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride include the possibility of contact dermatitis, asthma or respiratory symptoms like runny nose, sore throat, or cough) . Allergic contact dermatitis is also a possibility . Direct eye and mucous membrane exposure resulting from inappropriate usage or administation of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride preparations can also occur. And as with most pharmaceutical agents, although ingestion and systemic absorption is possible, ingestion of appropriately dilute solutions of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is unlikely to be serious .
Food Interaction
No interactions found.Volume of Distribution
Readily accessible data regarding the volume of distribution of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is not available.
Elimination Route
Quaternary ammonium compounds are poorly absorbed by the oral route of administration . At the same time, systemic effects from percutaneous absorption through intact skin is considered rare as well . Nevertheless, although potentially minimal, systemic absorption is possible .
Half Life
Readily accessible data regarding the half-life of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is not available.
Clearance
Readily accessible data regarding the clearance of n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is not available.
Elimination Route
As quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is poorly absorbed by the oral route, relatively large amounts of the agent that is absorbed is likely to be eliminated in the faeces .
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