Novoquine

Novoquine Uses, Dosage, Side Effects, Food Interaction and all others data.

A 4-aminoquinoquinoline compound with anti-inflammatory properties.

Novoquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. Novoquine is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension. They depress respiration and cause diplopia, dizziness and nausea.

Novoquine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Novoquine
Generic	Amodiaquine
Amodiaquine Other Names	Amodiaquina, Amodiaquine, Amodiaquinum
Weight	150mg/5ml, 150mg
Type	Suspension, Tablet
Formula	C₂₀H₂₂ClN₃O
Weight	Average: 355.861 Monoisotopic: 355.145140048
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Krka-pak Pharmaceutical & Chemical Works
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Novoquine is an antimalarial drug.

For treatment of acute malarial attacks in non-immune subjects.

How Novoquine works

The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. The drug binds the free heme preventing the parasite from converting it to a form less toxic. This drug-heme complex is toxic and disrupts membrane function.

Toxicity

LD₅₀ (mouse, intraperitoneal) 225 mg/kg, LD₅₀ (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.