Phenylbenzimidazole Sulfonic Acid
Phenylbenzimidazole Sulfonic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Phenylbenzimidazole Sulfonic Acid, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly used in products formulated to feel light and less oily . It was demonstrated by studies that ensulizole treatment provided protection against cyclobutane pyrimidine dimers and photosensitized the formation of oxidized guanine bases after UV-A or UV-B exposure . According to the FDA, the maximal approved concentration of ensulizole is 148 mM although concentrations ranging between 74 and 148mM can be found in commercial sunscreen products .
Phenylbenzimidazole Sulfonic Acid is a selective UV-B filter with little activity against UV-A wavelengths. In vitro, ensulizole oxidizes guanine bases upon photoexcitation by UV-B and may cause photodamage on DNA, proteins and lipids in the cellular context .
Trade Name | Phenylbenzimidazole Sulfonic Acid |
Generic | Ensulizole |
Ensulizole Other Names | Ensulizole, phenylbenzimidazole sulfonic acid |
Type | |
Formula | C13H10N2O3S |
Weight | Average: 274.29 Monoisotopic: 274.041213364 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Phenylbenzimidazole Sulfonic Acid is an ingredient used in sunscreens to absorb UVB radiation.
Indicated to be used as an UV-B-absorbing molecule in sunscreen formulations.
How Phenylbenzimidazole Sulfonic Acid works
Phenylbenzimidazole Sulfonic Acid strongly absorbs UV-B wavelengths. It offers protection against UV-B-induced cyclobutane pyrimidine dimers . Based on the findings in vitro and in cellulo, ensulizole induces damage on the DNA, causes DNA strand breaks and photosensitizes the formation of oxidized guanines via type I and II photosensitization mechanisms following UV-A or UV-B irradiation . Phenylbenzimidazole Sulfonic Acid is capable of generating reactive oxygen species, including singlet oxygen upon photoexcitation .
Toxicity
Dermal LD50 in rat is > 3000 mg/kg and oral LD50 in rat is > 16000 mg/kg .
Food Interaction
No interactions found.Innovators Monograph
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