Sitamaquine Uses, Dosage, Side Effects and more
Sitamaquine (WR-6026) is an orally active 8-aminoquinoline analog in development by the Walter Reed Army Institute, in collaboration with GlaxoSmithKline (formerly SmithKline Beecham), for the potential treatment of visceral leishmaniasis.
| Trade Name | Sitamaquine |
| Generic | Sitamaquine |
| Sitamaquine Other Names | Sitamaquine |
| Type | |
| Formula | C21H33N3O |
| Weight | Average: 343.5062 Monoisotopic: 343.262362693 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in infectious and parasitic disease (unspecified).
How Sitamaquine works
The mechanism of plasmodicidal action of sitamaquine is not completely understood. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.
