Tetrodotoxin

Tetrodotoxin Uses, Dosage, Side Effects, Food Interaction and all others data.

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction. Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.

Tetrodotoxin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Tetrodotoxin
Generic	Tetrodotoxin
Tetrodotoxin Other Names	Tetrodotoxin
Type
Formula	C₁₁H₁₇N₃O₈
Weight	Average: 319.268 Monoisotopic: 319.101564535
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.

How Tetrodotoxin works

Tetrodotoxin binds to site 1 of the fast voltage-gated sodium channel located at the extracellular pore opening. The binding of any molecules to this site will temporarily disable the function of the ion channel. Saxitoxin and several of the conotoxins also bind the same site.