Tetrodotoxin

Tetrodotoxin Uses, Dosage, Side Effects, Food Interaction and all others data.

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction. Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.

Table Of contents

• Tetrodotoxin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Tetrodotoxin
Generic	Tetrodotoxin
Tetrodotoxin Other Names	Tetrodotoxin
Type
Formula	C11H17N3O8
Weight	Average: 319.268 Monoisotopic: 319.101564535
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.

How Tetrodotoxin works

Tetrodotoxin binds to site 1 of the fast voltage-gated sodium channel located at the extracellular pore opening. The binding of any molecules to this site will temporarily disable the function of the ion channel. Saxitoxin and several of the conotoxins also bind the same site.

Toxicity

Death has occurred within 17 minutes of ingestion.

Innovators Monograph

You find simplified version here Tetrodotoxin