Activated Protein C

Activated Protein C Uses, Dosage, Side Effects, Food Interaction and all others data.

Activated Protein C is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Activated Protein C was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.

Activated Protein C is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.Activated Protein C inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Activated Protein C
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Activated Protein C
Generic	Drotrecogin alfa
Drotrecogin alfa Other Names	Activated protein C, Blood coagulation factor XIV (human), Drotrecogin alfa (activated), Drotrecogin alfa (activated), lyophilized, Drotrecogin alfa activated, Drotrecogin alfa, activated, Drotrecogin-alfa, Recombinant human activated protein C (rH-APC)
Type
Formula	C₁₇₈₆H₂₇₇₉N₅₀₉O₅₁₉S₂₉
Weight	55000.0 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
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Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Activated Protein C is a form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

For reduction of mortality in patients with severe sepsis.

How Activated Protein C works

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.