Blood Coagulation Factor XIV (human)

Blood Coagulation Factor XIV (human) Uses, Dosage, Side Effects, Food Interaction and all others data.

Blood Coagulation Factor XIV (human) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Blood Coagulation Factor XIV (human) was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.

Blood Coagulation Factor XIV (human) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.Blood Coagulation Factor XIV (human) inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Table Of contents

• Blood Coagulation Factor XIV (human)
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Blood Coagulation Factor XIV (human)
Generic	Drotrecogin alfa
Drotrecogin alfa Other Names	Activated protein C, Blood coagulation factor XIV (human), Drotrecogin alfa (activated), Drotrecogin alfa (activated), lyophilized, Drotrecogin alfa activated, Drotrecogin alfa, activated, Drotrecogin-alfa, Recombinant human activated protein C (rH-APC)
Type
Formula	C1786H2779N509O519S29
Weight	55000.0 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Blood Coagulation Factor XIV (human) is a form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

For reduction of mortality in patients with severe sepsis.

How Blood Coagulation Factor XIV (human) works

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.

Food Interaction

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Half Life

5.5 hours (mammalian reticulocytes, in vitro).

Clearance

• 40 L/hr [severe sepsis adults]
• 30 +/- 8 L/hr [patients without sepsis undergoing hemodialysis]
• 28 +/- 9 L/hr [heathy]

Innovators Monograph

You find simplified version here Blood Coagulation Factor XIV (human)