AR-9281
AR-9281 Uses, Dosage, Side Effects, Food Interaction and all others data.
AR-9281 inhibits soluble epoxide hydrolase.
| Trade Name | AR-9281 |
| Generic | AR-9281 |
| AR-9281 Other Names | APAU |
| Type | |
| Formula | C18H29N3O2 |
| Weight | Average: 319.449 Monoisotopic: 319.225977186 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in hypertension.
How AR-9281 works
AR9281 inhibits soluble epoxide hydrolase (s-EH), an enzyme that plays a key role in the cytochrome P450 pathway of arachidonic acid metabolism. Nuclear factor alpha B (NF-alphaB) is a transcription factor implicated in cardiac hypertrophy, and can be anti or pro apoptotic under different conditions. Epoxyeicosatrienoic acids (EETs), a product of cytochrome P450 epoxygenase enzyme action, have a variety of anti-hypertensive and anti-inflammatory effects. EETs have a vasodilatory action similar to endothelium derived hyperpolarizing factor and may inhibit NF-alphaB through a currently unknown mechanism. The enzyme s-EH catalyzes the breakdown of EETs to dihydroxyeicosatrienoic acids. AR9281's inhibition of s-EH enhances EETs anti-hypertensive and anti-inflammatory activities by preventing their breakdown by s-EH, as well as inhibiting NF-alphaB.
Innovators Monograph
You find simplified version here AR-9281
