Disulfide With Human Monoclonal Light Chain
Disulfide With Human Monoclonal Light Chain Uses, Dosage, Side Effects, Food Interaction and all others data.
Disulfide With Human Monoclonal Light Chain is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by the FDA in January 2020 for the treatment of TED. Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive surgeries - teprotumumab is the first drug ever approved for the treatment of TED and therefore represents a significant step forward in the treatment this disease.
Disulfide With Human Monoclonal Light Chain inhibits the downstream effects of IGF-1R signaling, namely tissue inflammation and remodeling, which are responsible for the various symptoms of thyroid eye disease. Disulfide With Human Monoclonal Light Chain may cause disease flares in patients with pre-existing inflammatory bowel disease (IBD) - patients experiencing an exacerbation should discontinue therapy with teprotumumab. Significant hyperglycemia has been observed in patients receiving treatment with teprotumumab which may require antihyperglycemic medications. Based on its mechanism of action, it is likely that teprotumumab will cause fetal harm in pregnant woman - for this reason, females of child-bearing age should use effective contraception prior to initiation, during therapy, and for 6 months following the last dose of teprotumumab.
| Trade Name | Disulfide With Human Monoclonal Light Chain |
| Availability | Prescription only |
| Generic | Teprotumumab |
| Teprotumumab Other Names | Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human monoclonal heavy chain), disulfide with human monoclonal light chain, dimer, Teprotumumab, teprotumumab-trbw |
| Related Drugs | Tepezza |
| Type | |
| Weight | 148000.0 Da (approximate) |
| Protein binding | Data regarding teprotumumab serum protein binding is unavailable at this time. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Disulfide With Human Monoclonal Light Chain is a fully human monoclonal antibody directed against insulin-like growth factor-1 receptor for the treatment of thyroid eye disease.
Disulfide With Human Monoclonal Light Chain is indicated for the treatment of thyroid eye disease.
Disulfide With Human Monoclonal Light Chain is also used to associated treatment for these conditions: Thyroid Eye Disease
How Disulfide With Human Monoclonal Light Chain works
Graves’ Disease is an autoimmune syndrome involving the thyroid, orbital connective tissues, and some regions of the skin. One manifestation of Graves’ Disease is thyroid-associated ophthalmopathy, or thyroid eye disease, which is characterized by orbital inflammation, tissue remodeling, and fibrosis. As the disease progresses, patients may develop proptosis, strabismus, corneal ulceration, and optic neuropathy. It has been demonstrated that insulin-like growth factor-1 receptors (IGF-1R) are overexpressed by orbital fibroblasts in patients with thyroid eye disease, in addition to being overexpressed on T-cells and B-cells in these patients. It was found that Graves’ Disease IgG molecules could mimic the principal ligand of IGF-1R, insulin-like growth factor-1 (IGF-1), and their binding of IGF-1R induces the expression of chemokines that play roles in tissue remodeling and inflammation. For these reasons, IGF-1R was sought after as a potential therapeutic target for the treatment of thyroid eye disease.
Disulfide With Human Monoclonal Light Chain is a fully human IgG1 monoclonal antibody directed against IGF-1R. It binds to and induces internalization and degradation of these receptors, thus preventing their downstream effects and alleviating symptoms of thyroid eye disease.
Toxicity
Toxicity information, including information regarding overdosage, is currently unavailable. Symptoms of teprotumumab overdose are likely to be consistent with its adverse effect profile.
Food Interaction
No interactions found.Disulfide With Human Monoclonal Light Chain Disease Interaction
Volume of Distribution
Following the standard dosing regimen, the mean central and peripheral volumes of distribution are approximately 3.26 ± 0.87 L and 4.32 ± 0.67 L, respectively.
Elimination Route
In a population of 40 patients receiving standard dosing in two clinical trials of teprotumumab, utilizing a two-compartment pharmacokinetic model, the AUC and Cmax were estimated to be 138 ± 34 mg•hr/mL and 632 ± 139 mcg/mL, respectively.
Half Life
The half-life of teprotumumab is 20 ± 5 days.
Clearance
The estimated mean clearance of teprotumumab is 0.27 L/day. The inter-compartment clearance is 0.74 L/day.
Elimination Route
Data regarding specific route(s) of elimination are unavailable at this time.
Innovators Monograph
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