Methiamide
Methiamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Methiamide is an H-2 receptor antagonist derived from burimamide. It was an intermediate product on the path to developing cimetidine.
Methiamide is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. Methiamide inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Methiamide include an increase in gastric bacterial flora such as nitrate-reducing organisms.
| Trade Name | Methiamide |
| Generic | Metiamide |
| Metiamide Other Names | Methiamide, Metiamida, Metiamide, Metiamidum |
| Type | |
| Formula | C9H16N4S2 |
| Weight | Average: 244.38 Monoisotopic: 244.081637912 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
How Methiamide works
Methiamide binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Innovators Monograph
You find simplified version here Methiamide
