Sparsentan
Sparsentan Uses, Dosage, Side Effects, Food Interaction and all others data.
Sparsentan has been used in trials studying the treatment of Focal Segmental Glomerulosclerosis. Sparsentan is the first and only dual-acting angiotensin and endothelin receptor antagonist (DARA) in development.
| Trade Name | Sparsentan |
| Generic | Sparsentan |
| Sparsentan Other Names | Sparsentan |
| Type | |
| Formula | C32H40N4O5S |
| Weight | Average: 592.76 Monoisotopic: 592.271941578 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How Sparsentan works
Sparsentan, which possesses two clinically validated mechanisms of action in a single molecule, works by selectively blocking the action of two potent vasoconstrictor and mitogenic agents, angiotensin II (AII) and endothelin 1 (ET1), at their respective receptors. Sparsentan is highly selective (10,000-fold) for the AII receptor sub-type 1 and the ET receptor sub-type A. As such, Sparsentan combines the properties of an angiotensin receptor blocker (ARB) and an endothelin receptor antagonist (ERA) in the same molecule.
Innovators Monograph
You find simplified version here Sparsentan
